Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 5/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766052 | 1.00 | SMG1 (0.47) | SMG1CDK1CDK2PIK3CAAKT1 | |
| SCHEMBL24766582 | 0.80 | SMG1 (0.48) | SMG1CDK1CDK2PIK3CAAKT1 | |
| SCHEMBL29434171 | 0.80 | SMG1 (0.48) | SMG1CDK1CDK2PIK3CAAKT1 | |
| SCHEMBL24766047 | 0.79 | MAPT (0.49) | MAPTNPSR1MEN1NPC1RAB9A | |
| SCHEMBL29434142 | 0.74 | CDK1 (0.52) | SMG1CDK1CDK2PIK3CAAKT1 | |
| SCHEMBL24766835 | 0.74 | CDK1 (0.52) | SMG1CDK1CDK2PIK3CAAKT1 | |
| SCHEMBL17204101 | 0.72 | MAPT (0.61) | MAPTTSHRMAPK1NPSR1HSD17B10 | |
| SCHEMBL3596552 | 0.71 | MAPT (0.49) | MAPTTSHRMAPK1NPSR1HSD17B10 | |
| SCHEMBL24766055 | 0.70 | PIM1 (0.49) | MAPTTSHRMAPK1NPSR1HSD17B10 | |
| SCHEMBL24766568 | 0.70 | ATR (0.57) | ATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |