Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 5/20 | 0.45 |
| ▸ | BRAF | P15056 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766582 | 1.00 | SMG1 (0.48) | SMG1CDK1CDK2RAF1BRAF | |
| SCHEMBL24766052 | 0.80 | SMG1 (0.47) | SMG1CDK1CDK2MAPTTSHR | |
| SCHEMBL29434093 | 0.80 | SMG1 (0.47) | SMG1CDK1CDK2MAPTTSHR | |
| SCHEMBL24766463 | 0.79 | CYP1A2 (0.50) | KDM4ELMNATDP1L3MBTL1MAPT | |
| SCHEMBL29434148 | 0.79 | CYP1A2 (0.50) | KDM4ELMNATDP1L3MBTL1MAPT | |
| SCHEMBL24766835 | 0.75 | CDK1 (0.52) | SMG1CDK1CDK2MAPTPIK3CA | |
| SCHEMBL29434142 | 0.75 | CDK1 (0.52) | SMG1CDK1CDK2MAPTPIK3CA | |
| SCHEMBL17204101 | 0.73 | MAPT (0.61) | KDM4EMAPTTSHRMAPK1NPSR1 | |
| SCHEMBL24766067 | 0.71 | LRRK2 (0.48) | MAPTTSHRMAPK1NPSR1HSD17B10 | |
| SCHEMBL24766568 | 0.71 | ATR (0.57) | ATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |