Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980440 | 1.00 | HSD11B1 (0.45) | HSD11B1EDNRBEDNRACCR4SLC40A1 | |
| SCHEMBL23010759 | 0.92 | HSD11B1 (0.45) | HSD11B1EDNRBEDNRACCR4SLC40A1 | |
| SCHEMBL29434807 | 0.92 | HSD11B1 (0.45) | HSD11B1EDNRBEDNRACCR4SLC40A1 | |
| SCHEMBL22980320 | 0.92 | HSD11B1 (0.45) | HSD11B1EDNRBEDNRACCR4SLC40A1 | |
| SCHEMBL29434862 | 0.92 | HSD11B1 (0.45) | HSD11B1EDNRBEDNRACCR4SLC40A1 | |
| SCHEMBL29434888 | 0.91 | SLC40A1 (0.44) | EDNRASLC40A1PTGES2BRAF | |
| SCHEMBL22980265 | 0.91 | SLC40A1 (0.44) | EDNRASLC40A1PTGES2BRAF | |
| SCHEMBL22980356 | 0.90 | PTGES2 (0.47) | CCR4MAP3K20PTGES2 | |
| SCHEMBL29434812 | 0.90 | PTGES2 (0.47) | CCR4MAP3K20PTGES2 | |
| SCHEMBL22980302 | 0.90 | MAP3K20 (0.44) | EDNRBEDNRACCR4MAP3K20PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013495-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-06-22 | — | — | EP | claimed |
| CN-114174266-A | Arylsulfonamide derivatives as MGLUR4 negative allosteric modulators | 豪夫迈·罗氏有限公司 | 2022-03-11 | — | — | CN | claimed |
| EP-4013495-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-06-22 | — | — | EP | disclosed |
| CN-114174266-A | Arylsulfonamide derivatives as MGLUR4 negative allosteric modulators | 豪夫迈·罗氏有限公司 | 2022-03-11 | — | — | CN | disclosed |