⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17639 | 1.00 | — | — | |
| SCHEMBL27768617 | 0.97 | — | — | |
| SCHEMBL3181216 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL8812851 | 0.97 | — | — | |
| Bromide SCHEMBL29506576 | 0.95 | NOS2 (0.91) | — | |
| SCHEMBL6859312 | 0.91 | NOS2 (0.83) | — | |
| SCHEMBL1181839 | 0.91 | NOS2 (0.83) | — | |
| Alcohol SCHEMBL28917587 | 0.89 | NOS2 (0.79) | — | |
| Ammonia Solution, Strong SCHEMBL3174065 | 0.89 | NOS2 (0.79) | — | |
| Ammonia Solution, Strong SCHEMBL3170954 | 0.85 | NOS2 (0.73) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116265460-B | Thiazole methyl pyridine amine compound and preparation method and application thereof | 湖南化工研究院有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-116265460-B | Thiazole methyl pyridine amine compound and preparation method and application thereof | 湖南化工研究院有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-116265460-B | Thiazole methyl pyridine amine compound and preparation method and application thereof | 湖南化工研究院有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116265460-A | Thiazole methyl pyridine amine compound and preparation method and application thereof | 湖南化工研究院有限公司 | 2023-06-20 | — | — | CN | disclosed |
| CN-116265460-A | Thiazole methyl pyridine amine compound and preparation method and application thereof | 湖南化工研究院有限公司 | 2023-06-20 | — | — | CN | disclosed |
| CN-116265460-A | Thiazole methyl pyridine amine compound and preparation method and application thereof | 湖南化工研究院有限公司 | 2023-06-20 | — | — | CN | disclosed |
| EP-4153576-A1 | NOTCH INHIBITORS AND USES THEREOF | StemSynergy Therapeutics, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |
| CN-115103843-A | Mesoionic insecticides | FMC公司 | 2022-09-23 | — | — | CN | disclosed |
| US-20220281823-A1 | PHENYL AND PYRIDINYL SUBSTITUTED IMIDAZOLES AS MODULATORS OF RORgT | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-08 | — | — | US | disclosed |
| EP-3959207-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2022-03-02 | — | — | EP | disclosed |