Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.54 |
| ▸ | INSR | P06213 | 6/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886504 | 0.97 | MET (0.57) | METINSRCDK2CCNKCCNA2 | |
| SCHEMBL886461 | 0.90 | MET (0.57) | METINSRCDK2CCNKCCNA2 | |
| SCHEMBL885690 | 0.87 | MET (0.57) | METINSRIGF1RPTK2SLC2A1 | |
| SCHEMBL16965975 | 0.85 | MET (0.55) | METINSRIGF1RPTK2EGFR | |
| SCHEMBL886201 | 0.85 | MET (0.68) | METINSRPTK2ALKAXL | |
| SCHEMBL2061961 | 0.84 | MET (0.59) | METINSRPTK2EGFRALK | |
| SCHEMBL2061111 | 0.84 | MET (0.54) | METINSRPTK2EGFRALK | |
| SCHEMBL2943633 | 0.83 | CCNK (0.42) | METINSRCDK2CCNKCCNA2 | |
| SCHEMBL2061747 | 0.80 | INSR (0.51) | METINSRCDK2CCNKCCNA2 | |
| SCHEMBL2061583 | 0.78 | ALK (0.65) | METINSRCDK2IGF1RPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |