Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.50 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171102 | 0.88 | BCAT2 (0.61) | BCAT2IKBKBKEAP1NFE2L2CHUK | |
| SCHEMBL29941849 | 0.78 | MKNK1 (0.55) | MKNK1MKNK2BCAT2IKBKBMAPK12 | |
| SCHEMBL8668460 | 0.77 | BCAT2 (0.74) | MKNK1MKNK2BCAT2KEAP1NFE2L2 | |
| SCHEMBL6303170 | 0.76 | MKNK1 (0.54) | MKNK1MKNK2MAP4K4CA2CA12 | |
| SCHEMBL3453931 | 0.76 | HNF4A (0.53) | MKNK1MKNK2BCAT2IKBKBMAPK12 | |
| SCHEMBL6903281 | 0.74 | BCAT2 (0.44) | BCAT2CA2CA1CA9KEAP1 | |
| SCHEMBL8517078 | 0.74 | BRD4 (0.41) | BCAT2IKBKBKEAP1NFE2L2 | |
| SCHEMBL28586126 | 0.73 | BCAT2 (0.62) | BCAT2MAP4K4IKBKBCHUKPTGS2 | |
| SCHEMBL30903647 | 0.73 | BCAT2 (0.62) | BCAT2IKBKBCA2CA12CA1 | |
| SCHEMBL17593027 | 0.73 | BCAT2 (0.62) | BCAT2IKBKBCA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-B1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LTD (GB) | 2010-08-18 | — | — | EP | disclosed |