Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | GRIA1 | P42261 | 9/20 | 0.51 |
| ▸ | CACNG8 | Q8WXS5 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190872 | 1.00 | AURKB (0.55) | AURKBAURKAGRIA1CACNG8ALDH1A1 | |
| SCHEMBL22190930 | 0.85 | AURKB (0.44) | AURKBAURKAGRIA1CACNG8ALDH1A1 | |
| SCHEMBL22191136 | 0.82 | MAPT (0.51) | AURKBAURKAGRIA1CACNG8ALDH1A1 | |
| SCHEMBL22191685 | 0.82 | RET (0.51) | AURKBAURKAGRIA1CACNG8ALDH1A1 | |
| SCHEMBL22190817 | 0.81 | GAA (0.54) | AURKBGRIA1CACNG8ALDH1A1MAPT | |
| SCHEMBL22190814 | 0.80 | GRIA1 (0.48) | AURKBAURKAGRIA1CACNG8ALDH1A1 | |
| SCHEMBL22191468 | 0.79 | HDAC3 (0.49) | AURKBAURKAGRIA1CACNG8MAPT | |
| SCHEMBL22191095 | 0.75 | PLK4 (0.50) | AURKBGRIA1CACNG8MAPTHDAC3 | |
| SCHEMBL22191365 | 0.75 | GRM5 (0.45) | AURKBAURKAGRIA1CACNG8CDK2 | |
| SCHEMBL22190851 | 0.74 | MAPT (0.48) | AURKAGRIA1CACNG8ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064146-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064146-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | CSNK1A1, MAP3K20, CSNK1G3 | AURKB 445/4885AURKA 541/4885GRIA1 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.