Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010757 | 1.00 | POLB (0.43) | POLBKDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL20943936 | 0.84 | CA12 (0.44) | LMNAGAATDP1ALDH1A1KMT2A | |
| SCHEMBL20943948 | 0.84 | IRAK4 (0.35) | POLBKDM4EL3MBTL1TDP1MEN1 | |
| SCHEMBL30437515 | 0.83 | KDM4E (0.41) | POLBKDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL642595 | 0.83 | KDM4E (0.51) | POLBKDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL31003190 | 0.83 | NPC1 (0.39) | POLBKDM4EL3MBTL1TDP1GFER | |
| SCHEMBL643332 | 0.82 | KDM4E (0.44) | POLBKDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL20839954 | 0.82 | ALDH1A1 (0.44) | POLBKDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL30114504 | 0.81 | IRAK4 (0.43) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL20944436 | 0.81 | RAB9A (0.51) | KDM4ELMNAL3MBTL1TDP1XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119350422-B | Deubiquitinase targeting chimeric compound and preparation method and application thereof | 中国药科大学 | 2025-04-04 | — | — | CN | disclosed |
| CN-119350422-A | Deubiquitinase targeting chimeric compound and preparation method and application thereof | 中国药科大学 | 2025-01-24 | — | — | CN | disclosed |
| CN-111655680-B | Hormone receptor modulators for the treatment of metabolic mutations and fibrotic conditions and disorders | 阿德利克斯股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| CN-111278821-B | Spiro compounds as farnesol X receptor modulators | 百时美施贵宝公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-110177783-B | Hormone receptor modulators for the treatment of metabolic conditions and disorders | 阿德利克斯股份有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-113292555-B | Preparation method of Tropifexor | 武汉纽瑞斯医药科技有限公司 | 2022-03-18 | — | — | CN | disclosed |