Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 8/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | POLL | Q9UGP5 | 7/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guttiferone F SCHEMBL31345886 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL19565392 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL4607088 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL23815760 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL23815758 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL23607580 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL23815733 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Guttiferone F SCHEMBL25049796 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Garcinol SCHEMBL294532 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 | |
| Garcinol SCHEMBL29395703 | 0.82 | EP300 (0.75) | EP300HDAC11KAT2BPTGESHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694622-B1 | POLYISOPRENYL BENZOPHENONES AS INHIBITORS OF HISTONE ACETYL TRANSFERASES AND USES THEREOF | JNCASR BANGALORE (IN) | 2012-03-14 | — | — | EP | disclosed |
| US-7402706-B2 | Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2008-07-22 | — | — | US | disclosed |
| US-20070254961-A1 | Polyisoprenylated Benzophenones and Their Isomers as Inhibitors of Histone Acetyltransferases and Uses thereof | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2007-11-01 | — | — | US | disclosed |
| EP-1694622-A2 | POLYISOPRENYL BENZOPHENONES AS INHIBITORS OF HISTONE ACETYL TRANSFERASES AND USES THEREOF | Jawaharlal Nehru Centre For Advanced Scientific Research (IN) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005047457-A2 | POLYISOPRENYL BENZOPHENONES AS INHIBITORS OF HISTONE ACETYL TRANSFERASES AND USES THEREOF | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254961-A1 | Polyisoprenylated Benzophenones and Their Isomers as Inhibitors of Histone Acetyltransferases and Uses thereof | EP300, BPTF, PHF2 | EP300 1/4885HDAC11 33/4885KAT2B 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.