Guttiferone F

Guttiferone F

SCHEMBL4607088

C=C(C)[C@H](CC=C(C)C)C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 9/20 0.75
HDAC11 Q96DB2 2/20 0.75
KAT2B Q92831 2/20 0.75
PTGES O14684 1/20 0.75
HDAC8 Q9BY41 1/20 0.75
POLL Q9UGP5 7/20 0.47
STAT1 P42224 1/20 0.47
MET P08581 3/20 0.45
SIRT2 Q8IXJ6 3/20 0.43
SIRT1 Q96EB6 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Garcinol SCHEMBL29395703 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Garcinol SCHEMBL294532 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL19565392 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL31345886 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815758 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815733 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23607580 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL25049796 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815760 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Xanthochymol SCHEMBL14867275 0.92 EP300 (0.63) EP300HDAC11KAT2BPTGESHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 WO claimed
CN-104940177-A Medical application of guttiferone F UNIV SHANGHAI OF T C M 2015-09-30 CN claimed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 US claimed
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 WO disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed
CN-104940177-B Medical application of vine flavone F 上海中医药大学 2020-06-26 CN disclosed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 US disclosed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 US disclosed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 US disclosed
CN-102212507-A Hypericum sampsonii hance benzophenone synthase and coding genes thereof INST BOTANY CAS 2011-10-12 CN disclosed
EP-1529025-B1 POLYISOPRENYLBENZOPHENONE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF SANOFI AVENTIS DEUTSCHLAND (DE) 2008-07-16 EP disclosed
US-6956061-B2 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-10-18 US disclosed
EP-1529025-A1 POLYISOPRENYLBENZOPHENONE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF Aventis Pharma Deutschland GmbH (DE) 2005-05-11 EP disclosed
US-20040082662-A1 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-04-29 US disclosed
WO-2004014831-A1 POLYISOPRENYLBENZOPHENONE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 EP300 917/4885HDAC11 1566/4885KAT2B 2513/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 EP300 917/4885HDAC11 1566/4885KAT2B 2513/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 EP300 1842/4885HDAC11 1735/4885KAT2B 645/4885
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF KLK3, ACP3, CASP3 EP300 602/4885HDAC11 564/4885KAT2B 720/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN EP300 642/4885HDAC11 861/4885KAT2B 735/4885
US-20040082662-A1 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof GGPS1, PGGT1B, GNPAT EP300 579/4885HDAC11 2663/4885KAT2B 2710/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF EP300 447/4885HDAC11 798/4885KAT2B 1273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.