Guttiferone F

Guttiferone F

SCHEMBL4607088

C=C(C)[C@H](CC=C(C)C)C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ EP300 Q09472 9/20 0.75
▸ HDAC11 Q96DB2 2/20 0.75
▸ KAT2B Q92831 2/20 0.75
▸ PTGES O14684 1/20 0.75
▸ HDAC8 Q9BY41 1/20 0.75
▸ POLL Q9UGP5 7/20 0.47
▸ STAT1 P42224 1/20 0.47
▸ MET P08581 3/20 0.45
▸ SIRT2 Q8IXJ6 3/20 0.43
▸ SIRT1 Q96EB6 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Garcinol SCHEMBL29395703 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL31345886 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL19565392 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815758 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815733 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23607580 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL25049796 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815760 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Garcinol SCHEMBL294532 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Xanthochymol SCHEMBL294395 0.92 EP300 (0.63) EP300HDAC11KAT2BPTGESHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 — — WO claimed
CN-104940177-A Medical application of guttiferone F UNIV SHANGHAI OF T C M 2015-09-30 — — CN claimed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 — — US claimed
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 — — WO disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 — — US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 — — US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 — — US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 — — US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 — — US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 — — US disclosed
CN-104940177-B Medical application of vine flavone F 上海中医药大学 2020-06-26 — — CN disclosed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 — — US disclosed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 — — US disclosed
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF HONG KONG BAPTIST UNIVERSITY (HK) 2015-01-22 — — US disclosed
CN-102212507-A Hypericum sampsonii hance benzophenone synthase and coding genes thereof INST BOTANY CAS 2011-10-12 — — CN disclosed
EP-1529025-B1 POLYISOPRENYLBENZOPHENONE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF SANOFI AVENTIS DEUTSCHLAND (DE) 2008-07-16 — — EP disclosed
US-6956061-B2 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-10-18 — — US disclosed
EP-1529025-A1 POLYISOPRENYLBENZOPHENONE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF Aventis Pharma Deutschland GmbH (DE) 2005-05-11 — — EP disclosed
US-20040082662-A1 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-04-29 — — US disclosed
WO-2004014831-A1 POLYISOPRENYLBENZOPHENONE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-02-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 EP300 917/4885HDAC11 1566/4885KAT2B 2513/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 EP300 917/4885HDAC11 1566/4885KAT2B 2513/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 EP300 1842/4885HDAC11 1735/4885KAT2B 645/4885
US-20150025155-A1 ANTI-PROSTATE CANCER COMPOUND AND METHOD OF USE THEREOF KLK3, ACP3, CASP3 EP300 602/4885HDAC11 564/4885KAT2B 720/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN EP300 642/4885HDAC11 861/4885KAT2B 735/4885
US-20040082662-A1 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof GGPS1, PGGT1B, GNPAT EP300 579/4885HDAC11 2663/4885KAT2B 2710/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF EP300 447/4885HDAC11 798/4885KAT2B 1273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback