Garcinol

Garcinol

SCHEMBL294532

C=C(C)[C@@H](CC=C(C)C)C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 9/20 0.75
HDAC11 Q96DB2 2/20 0.75
KAT2B Q92831 2/20 0.75
PTGES O14684 1/20 0.75
HDAC8 Q9BY41 1/20 0.75
POLL Q9UGP5 7/20 0.47
STAT1 P42224 1/20 0.47
MET P08581 3/20 0.45
SIRT2 Q8IXJ6 3/20 0.43
SIRT1 Q96EB6 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Garcinol SCHEMBL29395703 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL19565392 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL31345886 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815758 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815733 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23607580 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL25049796 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL23815760 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Guttiferone F SCHEMBL4607088 1.00 EP300 (0.75) EP300HDAC11KAT2BPTGESHDAC8
Xanthochymol SCHEMBL14867275 0.92 EP300 (0.63) EP300HDAC11KAT2BPTGESHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1026 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605407-B2 Methods to induce terminal differentiation in stem cells by interfering with DNA replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-04-21 US claimed
EP-4725505-A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR SKIN DISORDER ASSOCIATED WITH HISTONE DEACETYLASE 4 ABNORMALITY National University Corporation Kobe University (JP) 2026-04-15 EP claimed
US-12496357-B2 Compositions and methods for treating sickle cell disease YALE UNIVERSITY (US) 2025-12-16 US claimed
US-20250075176-A1 COMPOSITIONS COMPRISING HISTONE ACETYLTRANSFERASE INHIBITORS OR REVERSE TRANSCRIPTASE INHIBITORS AND USE THEREOF FOREVE LABS LTD. (IL) 2025-03-06 US claimed
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 WO claimed
EP-4490269-A1 COMPOSITIONS COMPRISING HISTONE ACETYLTRANSFERASE INHIBITORS OR REVERSE TRANSCRIPTASE INHIBITORS AND USE THEREOF Foreve Labs Ltd. (IL) 2025-01-15 EP claimed
WO-2025009296-A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR SKIN DISORDER ASSOCIATED WITH HISTONE DEACETYLASE 4 ABNORMALITY 国立大学法人神戸大学 2025-01-09 WO claimed
WO-2024233640-A1 COMPOSITIONS AND METHODS FOR INHIBITING SEIZURES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-11-14 WO claimed
US-20240366661-A1 COMPOSITIONS FOR AND METHODS OF TREATING A SUBJECT HAVING INFLAMMATION THE GEORGE WASHINGTON UNIVERSITY 2024-11-07 US claimed
US-20240269106-A1 SMALL MOLECULE MODULATOR TARGETING A RARE HISTONE MODIFICATION REGULATING ADIPOGENESIS AND PHARMACEUTICAL FORMULATION THEREOF COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN (IN) 2024-08-15 US claimed
EP-1254209-B1 COMPOSITION COMPRISING HYDROXYCITRIC ACID AND GARCINOL FOR WEIGHT-LOSS SABINSA CORP (US) 2006-03-15 EP claimed
WO-2005025500-A2 PROCESS FOR PREPARING WATER SOLUBLE DITERPENES AND THEIR APPLICATIONS MAJEED MUHAMMED (US) 2005-03-24 WO claimed
US-20050051483-A1 Process for preparing water soluble diterpenes and their applications SAMI LABS LTD. (IN) 2005-03-10 US claimed
EP-1254209-A4 BIOAVAILABLE COMPOSITION OF NATURAL AND SYNTHETIC HCA SABINSA CORP (US) 2004-09-08 EP claimed
CN-1521164-A Pyran isoflavone molluscacide synthesizing method and formulation 中国人民解放军南京军区联勤部军事医 2004-08-18 CN claimed
US-20020187943-A1 Bioavailable composition of natural and synthetic hca SAMI LABS LTD. (IN) 2002-12-12 US claimed
EP-1254209-A2 BIOAVAILABLE COMPOSITION OF NATURAL AND SYNTHETIC HCA Sabinsa Corporation (US) 2002-11-06 EP claimed
WO-2002060865-A1 PROCESS OF OBTAINING HIGH PURITY OF ZEAXANTHIN, CRYPTOXANTHIN & OTHER CAROTENOIDS FROM BYADAGI CHILI/CHAPPATTA CHILI & CAROTENOID COMPOSITION SABINSA CORPORATION (US) 2002-08-08 WO claimed
WO-2002014477-A2 BIOAVAILABLE COMPOSITION OF NATURAL AND SYNTHETIC HCA SABINSA CORPORATION (US) 2002-02-21 WO claimed
US-5972357-A CONTAINING POLYISOPRENYLATED BENZOPHENONE DERIVATIVES AS EFFECTIVE INGREDIENTS AND HAVING A VARIETY OF FUNCTIONS FOR MAINTAINING HEALTH SUCH AS ANTI-ULCER ACTIVITY, THE MAILLARD REACTION INHIBITING ACTIVITY, ANTI-OXIDATION ACTIVITY, OXYGEN KIKKOMAN CORPORATION (JP) 1999-10-26 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12496357-B2 Compositions and methods for treating sickle cell disease HBB, HBG1, HBZ EP300 4879/4885HDAC11 4747/4885KAT2B 4349/4885
US-12605407-B2 Methods to induce terminal differentiation in stem cells by interfering with DNA replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof CCND1, CCNB3, MKI67 EP300 2856/4885HDAC11 3213/4885KAT2B 2199/4885
US-20240269106-A1 SMALL MOLECULE MODULATOR TARGETING A RARE HISTONE MODIFICATION REGULATING ADIPOGENESIS AND PHARMACEUTICAL FORMULATION THEREOF EP300, HDAC1, HDAC3 EP300 1/4885HDAC11 5/4885KAT2B 37/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.