Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.51 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.50 |
| ▸ | YAP1 | P46937 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 4/20 | 0.45 |
| ▸ | CCR6 | P51684 | 3/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496005 | 1.00 | TNNI3K (0.51) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL24496013 | 0.88 | TEAD1 (0.49) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL24496260 | 0.84 | TEAD1 (0.51) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL29648401 | 0.84 | TEAD1 (0.51) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL22718227 | 0.83 | TNNI3K (0.54) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL29438827 | 0.83 | TNNI3K (0.54) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL24496353 | 0.81 | TEAD1 (0.57) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL22718299 | 0.80 | TEAD1 (0.57) | TNNI3KTEAD1YAP1BRAFCCR6 | |
| SCHEMBL22718190 | 0.80 | TEAD1 (0.77) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL29438880 | 0.80 | TEAD1 (0.77) | TNNI3KTEAD1YAP1MAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561061-A | Combination of 3- (imidazol-4-yl) -4- (amino) -benzenesulfonamide TEAD inhibitors with EGFR inhibitors and/or MEK inhibitors for the treatment of lung cancer | 医肯纳肿瘤学公司 | 2024-02-13 | — | — | CN | disclosed |
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022159986-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2022-07-28 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |