Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.66 |
| ▸ | YAP1 | P46937 | 1/20 | 0.66 |
| ▸ | TLR2 | O60603 | 4/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718065 | 1.00 | TEAD1 (0.66) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL24496290 | 0.87 | TEAD1 (0.50) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL22718245 | 0.87 | TEAD1 (0.74) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL22718330 | 0.84 | TEAD1 (0.67) | TEAD1YAP1TLR2TLR1TSHR | |
| SCHEMBL22718064 | 0.84 | TEAD1 (0.65) | TEAD1YAP1TLR2TLR1TRPV1 | |
| SCHEMBL22718356 | 0.83 | TEAD1 (0.60) | TEAD1YAP1KDM4ETSHRCASP6 | |
| SCHEMBL29648434 | 0.81 | TEAD1 (0.65) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL29438825 | 0.80 | TEAD1 (0.61) | TEAD1YAP1TLR2TLR1MOGAT2 | |
| SCHEMBL22718414 | 0.80 | TEAD1 (0.61) | TEAD1YAP1TLR2TLR1MOGAT2 | |
| SCHEMBL20779435 | 0.80 | TEAD1 (1.00) | TEAD1YAP1TLR2TLR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |