Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.63 |
| ▸ | YAP1 | P46937 | 1/20 | 0.63 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718358 | 1.00 | TEAD1 (0.63) | TEAD1YAP1TNNI3KALDH1A1MAPK1 | |
| SCHEMBL29438880 | 0.87 | TEAD1 (0.77) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL22718190 | 0.87 | TEAD1 (0.77) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL24788980 | 0.85 | TEAD1 (0.66) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL30135282 | 0.85 | TEAD1 (0.66) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL22843416 | 0.84 | TEAD1 (0.45) | TEAD1YAP1TNNI3KALDH1A1MAPK1 | |
| SCHEMBL22718188 | 0.83 | TEAD1 (0.66) | TEAD1YAP1TNNI3KALDH1A1BRAF | |
| SCHEMBL29438838 | 0.83 | TEAD1 (0.66) | TEAD1YAP1TNNI3KALDH1A1BRAF | |
| SCHEMBL24496007 | 0.83 | TEAD1 (0.58) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29648310 | 0.83 | TEAD1 (0.58) | TEAD1YAP1TNNI3KBRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |