Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | PDE8B | O95263 | 12/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22715592 | 1.00 | PDE10A (0.45) | PDE10APDE8BKDM4ELMNAMAPT | |
| SCHEMBL29439675 | 0.74 | DHFR (0.53) | DHFRMAP4K4 | |
| SCHEMBL3922711 | 0.74 | DHFR (0.53) | DHFRMAP4K4 | |
| SCHEMBL4095470 | 0.73 | ACHE (0.35) | HSD17B10DHFRMAP4K4ACHE | |
| SCHEMBL15265691 | 0.73 | PRMT5 (0.42) | PDE10APDE8BKDM4ELMNAMAPT | |
| SCHEMBL22715815 | 0.72 | DHFR (0.36) | HTTDHFRMAP4K4 | |
| SCHEMBL22715191 | 0.72 | ADORA1 (0.41) | KDM4EMAPTHTTDHFRMAP4K4 | |
| SCHEMBL22744486 | 0.72 | DHFR (0.36) | DHFRMAP4K4 | |
| SCHEMBL29439784 | 0.72 | ADORA1 (0.41) | KDM4EMAPTHTTDHFRMAP4K4 | |
| SCHEMBL22715906 | 0.72 | DHFR (0.37) | DHFRMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |