Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22715327 | 1.00 | CDC7 (0.35) | CDC7DBF4STK17BALDH1A1LMNA | |
| SCHEMBL22715176 | 0.82 | IKBKB (0.33) | ALDH1A1LMNATP53HSD17B10IKBKB | |
| SCHEMBL22715917 | 0.82 | IKBKB (0.44) | CDC7DBF4ALDH1A1TP53HSD17B10 | |
| SCHEMBL29439677 | 0.82 | IKBKB (0.33) | ALDH1A1LMNATP53HSD17B10IKBKB | |
| SCHEMBL29439756 | 0.82 | IKBKB (0.44) | CDC7DBF4ALDH1A1TP53HSD17B10 | |
| SCHEMBL29439774 | 0.79 | LIMK1 (0.35) | EGFRTYK2 | |
| SCHEMBL22715521 | 0.79 | LIMK1 (0.35) | EGFRTYK2 | |
| SCHEMBL793082 | 0.76 | TYK2 (0.51) | CDC7DBF4ALDH1A1LMNATP53 | |
| SCHEMBL23172713 | 0.68 | RAB9A (0.40) | ALDH1A1LMNATP53HSD17B10 | |
| SCHEMBL22715976 | 0.68 | PIK3CG (0.59) | IKBKBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |