Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.77 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.77 |
| ▸ | GSK3B | P49841 | 3/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.77 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.68 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.61 |
| ▸ | SYK | P43405 | 2/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945641 | 0.91 | MAPK8 (0.67) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL2944431 | 0.88 | CAMKK2 (0.77) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL2944088 | 0.85 | ABL1 (0.64) | CAMKK2MAPK8GSK3BPIK3CGCAMK2D | |
| SCHEMBL3747896 | 0.83 | CAMKK2 (0.80) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL8084736 | 0.82 | JAK2 (0.76) | SYKIKBKBPLK1JAK2 | |
| SCHEMBL4737537 | 0.82 | SYK (0.67) | CAMKK2MAPK8GSK3BPIK3CGCAMK2D | |
| SCHEMBL4903516 | 0.82 | MAPK8 (0.68) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL8246523 | 0.81 | MAPK8 (1.00) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL14254013 | 0.81 | PIK3CG (0.57) | CAMKK2MAPK8GSK3BPIK3CGSYK | |
| SCHEMBL4800404 | 0.80 | MAPK8 (0.83) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172460-A1 | Compositions useful as inhibitors of JAK and other protein kinases | Vertex Pharmaceuticals Incorporated (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-1562911-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2010-01-06 | — | — | EP | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| EP-1562911-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040147507-A1 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-07-29 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147507-A1 | Compositions useful as inhibitors of JAK and other protein kinases | JAK1, JAK2, JAK3 | CAMKK2 327/4885MAPK8 173/4885GSK3B 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.