Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.67 |
| ▸ | GSK3B | P49841 | 2/20 | 0.67 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.67 |
| ▸ | SYK | P43405 | 3/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 4/20 | 0.60 |
| ▸ | BCR | P11274 | 4/20 | 0.60 |
| ▸ | PRKCA | P17252 | 3/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | YES1 | P07947 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | FGR | P09769 | 1/20 | 0.58 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.58 |
| ▸ | CSK | P41240 | 1/20 | 0.58 |
| ▸ | TXK | P42681 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944084 | 0.91 | CAMKK2 (0.77) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL3012944 | 0.88 | ABL1 (0.70) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL3747896 | 0.88 | CAMKK2 (0.80) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL4737537 | 0.87 | SYK (0.67) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL3758823 | 0.87 | MAPK8 (0.76) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL4895454 | 0.86 | ABL1 (0.80) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| Hydrochloric Acid SCHEMBL27711429 | 0.85 | ABL1 (0.79) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL4903516 | 0.84 | MAPK8 (0.68) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL6752978 | 0.84 | CDK1 (0.66) | MAPK8PIK3CGGSK3BCAMKK2SYK | |
| SCHEMBL2939791 | 0.84 | PIK3CG (0.68) | MAPK8PIK3CGGSK3BCAMKK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172460-A1 | Compositions useful as inhibitors of JAK and other protein kinases | Vertex Pharmaceuticals Incorporated (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-1562911-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2010-01-06 | — | — | EP | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| EP-1562911-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040147507-A1 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-07-29 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147507-A1 | Compositions useful as inhibitors of JAK and other protein kinases | JAK1, JAK2, JAK3 | MAPK8 173/4885PIK3CG 109/4885GSK3B 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.