Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Verapamil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 3/20 | 1.00 |
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 1.00 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 1.00 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | ABCC1 | P33527 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Verapamil SCHEMBL29450374 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| (S)-Verapamil SCHEMBL29768846 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Dexverapamil SCHEMBL30402443 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL29450364 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL29064783 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL16742 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Dexverapamil SCHEMBL33297 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Dexverapamil SCHEMBL29423253 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL1902363 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| (S)-Verapamil SCHEMBL14874635 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117170276-A | Temperature detection and intelligent control system based on small microcomputer | 中国航空工业集团公司西安航空计算技术研究所 | 2023-12-05 | — | — | CN | claimed |
| US-12487235-B2 | Compositions and methods for studying drug metabolism | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-12-02 | — | — | US | disclosed |
| CN-115209733-B | Stable agrochemical composition | UPL毛里求斯有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-117597327-A | Pharmaceutical preparation | 第一波动生物制药股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117170276-A | Temperature detection and intelligent control system based on small microcomputer | 中国航空工业集团公司西安航空计算技术研究所 | 2023-12-05 | — | — | CN | disclosed |
| CN-110062624-B | Application of dihydro berberine compound in preparation of medicines for treating STAT3 signal path related tumor diseases | 中国医学科学院药物研究所 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023055163-A1 | METHOD AND APPARATUS FOR RECOMMENDING NUTRITIONAL SUPPLEMENTS OR NUTRITIONAL SOURCES ON BASIS OF ARTIFICIAL INTELLIGENCE | 주식회사 온택트헬스 | 2023-04-06 | — | — | WO | disclosed |
| EP-4052279-A1 | ION SOURCE | Micromass UK Limited (GB) | 2022-09-07 | — | — | EP | disclosed |
| US-11416543-B2 | Exam prefetching based on subject anatomy | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2022-08-16 | — | — | US | disclosed |
| US-11389171-B2 | Integrated system for the infixion and retrieval of implants | GOLDSMITH DAVID S (US) | 2022-07-19 | — | — | US | disclosed |
| CN-114559749-A | Transfer printer and method | 录象射流技术公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-114269384-A | Compositions for modulating the effects of botulinum neurotoxins | 法斯托克斯制药有限公司 | 2022-04-01 | — | — | CN | disclosed |