Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944050 | 0.85 | SIRT6 (0.43) | SIRT6ALDH1A1MAPTHTR6EGFR | |
| SCHEMBL2944154 | 0.83 | SIRT6 (0.56) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL520015 | 0.75 | SIRT6 (1.00) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL884828 | 0.75 | MEN1 (0.43) | ALDH1A1MAPT | |
| SCHEMBL2207091 | 0.71 | SIRT6 (0.90) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL17411235 | 0.69 | SIRT6 (0.81) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL17164781 | 0.68 | SIRT6 (0.82) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL1527207 | 0.67 | SIRT6 (0.80) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL29537193 | 0.67 | SIRT6 (0.80) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL29788578 | 0.66 | ALDH1A1 (1.00) | SIRT6ALDH1A1LMNAMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |