Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23780720 | 1.00 | NUDT1 (0.61) | NUDT1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL31347077 | 0.86 | KDM4E (0.58) | NUDT1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2158555 | 0.86 | KDM4E (0.58) | NUDT1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14760220 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL29904837 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL2158798 | 0.78 | KDM4E (0.41) | NUDT1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL10110217 | 0.77 | NUDT1 (0.43) | NUDT1JAK3JAK1JAK2 | |
| SCHEMBL31716012 | 0.77 | HPGD (0.54) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL256760 | 0.76 | NUDT1 (1.00) | NUDT1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL29678449 | 0.76 | NUDT1 (1.00) | NUDT1KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174292-B | Substituted 2-morpholinopyridine derivatives as ATR kinase inhibitors | 修复治疗公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-114174292-A | Substituted 2-morpholinopyridine derivatives as ATR kinase inhibitors | 修复治疗公司 | 2022-03-11 | — | — | CN | disclosed |