Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904893 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL22905022 | 0.93 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL29693898 | 0.93 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL29443113 | 0.93 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL24772450 | 0.92 | KDM4E (0.51) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL24771133 | 0.91 | KDM4E (0.49) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL24771130 | 0.91 | KDM4E (0.49) | KDM4EALDH1A1MAPK1L3MBTL1KMT2A | |
| SCHEMBL22904894 | 0.88 | MCL1 (0.43) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL29443069 | 0.88 | MCL1 (0.43) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL22909073 | 0.83 | JAK2 (0.46) | KDM4EALDH1A1MAPK1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206880-B | Benzothiophene, thienopyridine and thienopyrimidine derivatives for modulating STING | CTXT私人有限公司 | 2024-12-06 | — | — | CN | disclosed |
| EP-3999184-A1 | BENZOTHIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES FOR THE MODULATION OF STING | CTXT Pty Limited (AU) | 2022-05-25 | — | — | EP | disclosed |
| CN-114206880-A | Benzothiophene, thienopyridine, and thienopyrimidine derivatives for modulation of STING | CTXT私人有限公司 | 2022-03-18 | — | — | CN | disclosed |