Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 3/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693898 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 | |
| SCHEMBL22905022 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 | |
| SCHEMBL22904893 | 0.93 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 | |
| SCHEMBL29443028 | 0.93 | KDM4E (0.52) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 | |
| SCHEMBL22904895 | 0.88 | CHEK2 (0.48) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 | |
| SCHEMBL29443061 | 0.88 | CHEK2 (0.48) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 | |
| SCHEMBL24772450 | 0.87 | KDM4E (0.51) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL24771133 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1MAPK1L3MBTL1STING1 | |
| SCHEMBL24771130 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1MAPK1L3MBTL1NPC1 | |
| SCHEMBL22904894 | 0.81 | MCL1 (0.43) | KDM4EALDH1A1MAPK1L3MBTL1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206880-B | Benzothiophene, thienopyridine and thienopyrimidine derivatives for modulating STING | CTXT私人有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-114206880-A | Benzothiophene, thienopyridine, and thienopyrimidine derivatives for modulation of STING | CTXT私人有限公司 | 2022-03-18 | — | — | CN | disclosed |