Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 6/20 | 0.41 |
| ▸ | TYK2 | P29597 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904894 | 1.00 | MCL1 (0.43) | MCL1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22904895 | 0.92 | CHEK2 (0.48) | MCL1MAPK1STING1VDRNR1H4 | |
| SCHEMBL29443061 | 0.92 | CHEK2 (0.48) | MCL1MAPK1STING1VDRNR1H4 | |
| SCHEMBL24772449 | 0.90 | JAK2 (0.50) | MCL1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22904893 | 0.88 | KDM4E (0.52) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29443028 | 0.88 | KDM4E (0.52) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24771134 | 0.88 | JAK2 (0.52) | MCL1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL24771131 | 0.88 | JAK2 (0.52) | MCL1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22905022 | 0.81 | KDM4E (0.52) | MAPK1STING1VDRNR1H4CHEK2 | |
| SCHEMBL29443113 | 0.81 | KDM4E (0.52) | MAPK1STING1VDRNR1H4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206880-B | Benzothiophene, thienopyridine and thienopyrimidine derivatives for modulating STING | CTXT私人有限公司 | 2024-12-06 | — | — | CN | disclosed |
| EP-3999184-A1 | BENZOTHIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES FOR THE MODULATION OF STING | CTXT Pty Limited (AU) | 2022-05-25 | — | — | EP | disclosed |
| CN-114206880-A | Benzothiophene, thienopyridine, and thienopyrimidine derivatives for modulation of STING | CTXT私人有限公司 | 2022-03-18 | — | — | CN | disclosed |