Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.49 |
| ▸ | TUBB | P07437 | 2/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13452985 | 1.00 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12528148 | 1.00 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL250345 | 0.85 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29443894 | 0.85 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL223844 | 0.85 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29776573 | 0.85 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL276805 | 0.84 | MDM2 (0.55) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL276804 | 0.84 | MDM2 (0.55) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL275835 | 0.82 | MDM2 (0.55) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL275836 | 0.82 | MDM2 (0.55) | MDM2TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545685-B2 | Dispiropyrrolidine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2026-02-10 | — | — | US | disclosed |
| US-20240246989-A1 | DISPIROPYRROLIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2024-07-25 | — | — | US | disclosed |
| US-20220106324-A1 | DISPIROPYRROLIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12545685-B2 | Dispiropyrrolidine derivatives | TP53, MDM2, TP53BP1 | MDM2 2/4885TUBB4A 2580/4885TUBB 1972/4885 |
| US-20240246989-A1 | DISPIROPYRROLIDINE DERIVATIVES | MDM2, TP53, TP53BP1 | MDM2 1/4885TUBB4A 3026/4885TUBB 3200/4885 |
| US-20220106324-A1 | DISPIROPYRROLIDINE DERIVATIVES | MDM2, TP53, TP53BP1 | MDM2 1/4885TUBB4A 3026/4885TUBB 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.