Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30062492 | 0.94 | TSHR (0.51) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL29444556 | 0.80 | FAAH (0.36) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL31222700 | 0.80 | TSHR (0.61) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL4006352 | 0.77 | TSHR (0.67) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL58561 | 0.76 | TSHR (0.49) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL30714073 | 0.76 | FAAH (0.34) | TSHRNPSR1RXFP1NPC1RAB9A | |
| Fluoride SCHEMBL6346 | 0.75 | TSHR (0.47) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL9483441 | 0.74 | TSHR (0.63) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL23146639 | 0.74 | TSHR (0.67) | TSHRNPSR1RXFP1KMT2ANPC1 | |
| SCHEMBL17103078 | 0.74 | TSHR (0.67) | TSHRNPSR1RXFP1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119367364-A | Substituted indazoles for the treatment and prevention of allergic and/or inflammatory diseases in animals | 拜耳动物保健有限责任公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-111699188-B | [1,2,4] triazolo [4,3-a ] pyrazin-8-one derivatives | 伊莱利利公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-109152771-B | Use of 2-substituted indazoles for the treatment and prevention of autoimmune diseases | 拜耳医药股份有限公司 | 2022-07-19 | — | — | CN | disclosed |
| CN-110305109-B | Novel substituted indazoles, method for the production thereof, pharmaceutical preparations containing same, and use thereof for producing medicaments | 拜耳医药股份有限公司 | 2022-04-08 | — | — | CN | disclosed |