Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277244 | 1.00 | TOP2A (0.48) | TOP2ABCHEACHEKITPDGFRA | |
| SCHEMBL24276806 | 0.91 | BCHE (0.45) | TOP2ABCHEACHEKITPDGFRA | |
| SCHEMBL9739759 | 0.82 | TOP2A (0.66) | TOP2AACHEMAPT | |
| SCHEMBL29445058 | 0.82 | ACHE (0.55) | TOP2ABCHEACHEKITMAPT | |
| SCHEMBL24276984 | 0.82 | ACHE (0.55) | TOP2ABCHEACHEKITMAPT | |
| SCHEMBL24276814 | 0.80 | ADORA3 (0.41) | TOP2ABCHEACHEKITPDGFRA | |
| SCHEMBL10413305 | 0.80 | KIT (0.53) | TOP2ABCHEACHEKITPDGFRA | |
| SCHEMBL24277131 | 0.79 | HASPIN (0.50) | TOP2ABCHEACHEADORA3ADORA2A | |
| SCHEMBL29445019 | 0.79 | HASPIN (0.50) | TOP2ABCHEACHEADORA3ADORA2A | |
| SCHEMBL24277794 | 0.77 | TOP2A (0.40) | TOP2ABCHEACHEADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210703-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | Expansion Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022055922-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | EXPANSION THERAPEUTICS, INC. (US) | 2022-03-17 | — | — | WO | disclosed |