Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277024 | 1.00 | MAOA (0.57) | MAOAMAOBPTGER4NPSR1POLB | |
| SCHEMBL24277018 | 0.83 | NPY5R (0.44) | MAOAMAOBPTGER4KDM4EHASPIN | |
| SCHEMBL24277130 | 0.82 | MAPT (0.55) | MAOAMAOBNPSR1TDP1KDM4E | |
| SCHEMBL24276869 | 0.82 | MAOA (0.52) | MAOAMAOBPTGER4NPSR1POLB | |
| SCHEMBL29445169 | 0.82 | MAOA (0.52) | MAOAMAOBPTGER4NPSR1POLB | |
| SCHEMBL21651446 | 0.81 | PTGER4 (0.73) | MAOAMAOBPTGER4NPSR1POLB | |
| SCHEMBL29493320 | 0.81 | PTGER4 (0.73) | MAOAMAOBPTGER4NPSR1POLB | |
| SCHEMBL24277027 | 0.79 | MAOA (0.48) | MAOAMAOBNPSR1POLBKDM4E | |
| SCHEMBL24277022 | 0.79 | NISCH (0.49) | MAOAMAOBHASPINCYP3A4NPY5R | |
| SCHEMBL29445103 | 0.79 | NISCH (0.49) | MAOAMAOBHASPINCYP3A4NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210703-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | Expansion Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022055922-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | EXPANSION THERAPEUTICS, INC. (US) | 2022-03-17 | — | — | WO | disclosed |