Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.50 |
| ▸ | ESRRG | P62508 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26947 | 0.93 | ESR1 (0.58) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Bromide SCHEMBL30239808 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| SCHEMBL30384659 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| SCHEMBL30136074 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Cesium SCHEMBL30136131 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Ammonia Solution, Strong SCHEMBL30540302 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Potassium SCHEMBL30136058 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Potassium SCHEMBL30894669 | 0.91 | ESR1 (0.56) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Phenol SCHEMBL30211186 | 0.90 | ESR1 (0.58) | ESR1ESR2ESRRGCYP3A4HPGD | |
| Methacrylic Acid SCHEMBL29440499 | 0.89 | ESR1 (0.43) | ESR1ESR2ESRRGCYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116102867-B | Polycarbonate composition resistant to cyclic vibration and preparation method thereof | 万华化学（宁波）有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119350796-A | 5VA high-flame-retardance ABS resin composition and preparation method thereof | 磐塑科技(江苏)有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-112185621-B | Cable material formula with cable cell fracture position calibration function | 江门市可利塑业有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-117327321-A | Transparent high-hardness polycarbonate material and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-01-02 | — | — | CN | claimed |
| CN-116102867-A | Polycarbonate composition resistant to cyclic vibration and preparation method thereof | 万华化学（宁波）有限公司 | 2023-05-12 | — | — | CN | claimed |
| CN-110669281-B | Special flame-retardant synergistic functional master batch for modifying polycarbonate and alloy thereof and preparation method thereof | 江苏万纳普新材料科技有限公司 | 2022-08-19 | — | — | CN | claimed |
| CN-111592742-B | High-temperature-resistant PPO/PBT material and preparation method thereof | 山东鲁泰控股集团有限公司石墨烯高分子复合材料研发中心 | 2022-04-22 | — | — | CN | claimed |
| EP-4745191-A1 | POLYVINYL CHLORIDE-BASED RESIN COMPOSITION, AND FILM PRODUCED THEREFROM | Riken Technos Corporation (JP) | 2026-05-20 | — | — | EP | disclosed |
| EP-4720194-A1 | POLYCARBONATE COPOLYMER COMPOSITIONS | SHPP Global Technologies B.V. (NL) | 2026-04-08 | — | — | EP | disclosed |
| US-12534299-B2 | Antimicrobial/antiviral conveyor belt | ASCEND PERFORMANCE MATERIALS OPERATIONS LLC (US) | 2026-01-27 | — | — | US | disclosed |
| EP-4650400-A1 | THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE FORMED OF SAME | Teijin Limited (JP) | 2025-11-19 | — | — | EP | disclosed |
| EP-3858934-B1 | ADHESIVE RESIN COMPOSITIONS AND LAMINATES USING SAME | RIKEN TECHNOS CORP (JP) | 2025-11-12 | — | — | EP | disclosed |
| EP-4596635-A1 | THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING SAME | Teijin Limited (JP) | 2025-08-06 | — | — | EP | disclosed |
| CN-108966653-B | Heat-aging-resistant low-halogen flame-retardant polyamide composition | 奥升德高性能材料公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-114641534-A | Resin composition and electronic and electrical device member | 三菱工程塑料株式会社 | 2022-06-17 | — | — | CN | disclosed |
| CN-111763486-B | Adhesive resin composition and laminate using same | 理研科技株式会社 | 2022-05-17 | — | — | CN | disclosed |
| US-20220127455-A1 | IMPELLER AND RESIN COMPOSITION THEREFOR | TEIJIN LIMITED (JP) | 2022-04-28 | — | — | US | disclosed |
| CN-111592742-B | High-temperature-resistant PPO/PBT material and preparation method thereof | 山东鲁泰控股集团有限公司石墨烯高分子复合材料研发中心 | 2022-04-22 | — | — | CN | disclosed |
| CN-110506079-B | Polyamide composition and molded article | 旭化成株式会社 | 2022-03-22 | — | — | CN | disclosed |
| CN-110691820-B | Reinforced polycarbonate resin composition | 帝人株式会社 | 2022-03-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12534299-B2 | Antimicrobial/antiviral conveyor belt | POLR1C, SLC30A6, ATP6V0C | ESR1 3999/4885ESR2 4355/4885ESRRG 4337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.