Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.63 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.49 |
| ▸ | CACNG8 | Q8WXS5 | 4/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31192609 | 0.78 | PDE3B (1.00) | PDE3BPDE3AGRIA1CACNG8CDC7 | |
| SCHEMBL29445912 | 0.76 | PDE3B (0.67) | PDE3BPDE3AGRIA1CACNG8GSK3B | |
| SCHEMBL26613863 | 0.74 | ALDH1A1 (0.49) | GSK3BEGFRCAMKK2MAPTMAPK9 | |
| SCHEMBL30633622 | 0.74 | ALDH1A1 (0.49) | GSK3BEGFRCAMKK2MAPTMAPK9 | |
| SCHEMBL29445939 | 0.72 | CYP17A1 (0.55) | ABL1 | |
| SCHEMBL29445919 | 0.72 | BRAF (0.47) | ADORA2AADORA2BADORA1PIK3CDABL1 | |
| SCHEMBL9903935 | 0.72 | CYP2D6 (0.60) | GSK3BEGFRCAMKK2MAPTMAPK13 | |
| SCHEMBL31690863 | 0.72 | JAK2 (0.65) | GSK3BKDRCDC7DYRK1AMAPK13 | |
| SCHEMBL10843819 | 0.71 | MAPT (0.46) | ADORA2BGSK3BEGFRCAMKK2CDC7 | |
| SCHEMBL29445972 | 0.71 | PDPK1 (0.48) | ADORA2AADORA2BGSK3BKDRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12011444-B2 | N-substituted indole derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-18 | — | — | US | disclosed |
| US-20220175775-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-06-09 | — | — | US | disclosed |
| US-11241431-B2 | N-substituted indole derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175775-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | PTGER1, PTGER4, PTGER2 | PDE3B 235/4885PDE3A 302/4885GRIA1 329/4885 |
| US-12011444-B2 | N-substituted indole derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | PDE3B 235/4885PDE3A 302/4885GRIA1 329/4885 |
| US-11241431-B2 | N-substituted indole derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | PDE3B 235/4885PDE3A 302/4885GRIA1 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.