Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | EDNRA | P25101 | 2/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | EDNRB | P24530 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25616772 | 0.84 | CA2 (0.57) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL28758462 | 0.82 | CA2 (0.53) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL29715252 | 0.80 | CA2 (0.65) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL18739981 | 0.80 | CA2 (0.65) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL922350 | 0.77 | CA2 (0.71) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL13590904 | 0.77 | CA2 (0.75) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL25387423 | 0.77 | EDNRB (0.50) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL30562770 | 0.77 | EDNRB (0.50) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL5032636 | 0.76 | KMT2A (0.71) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL10680402 | 0.75 | KEAP1 (0.48) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4007752-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| CN-114302880-A | KIF18A inhibitors | 美国安进公司 | 2022-04-08 | — | — | CN | disclosed |