SCHEMBL29448485

SCHEMBL29448485

Cc1c[nH]c2nc(Cl)nc(N[C@@H]3CCCN(C(=O)OC(C)(C)C)C3)c12

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
JAK3 P52333 15/20 0.52
BTK Q06187 13/20 0.49
PIM1 P11309 2/20 0.43
PIM2 Q9P1W9 2/20 0.43
USP30 Q70CQ3 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29448486 1.00 JAK3 (0.52) JAK3BTKPIM1PIM2USP30
SCHEMBL22496733 1.00 JAK3 (0.52) JAK3BTKPIM1PIM2USP30
SCHEMBL28918226 1.00 JAK3 (0.52) JAK3BTKPIM1PIM2USP30
SCHEMBL22497106 0.92 BTK (0.54) JAK3BTK
SCHEMBL22496749 0.92 BTK (0.54) JAK3BTK
SCHEMBL29448477 0.92 BTK (0.54) JAK3BTK
SCHEMBL22496761 0.88 JAK3 (0.53) JAK3BTKUSP30
SCHEMBL29448488 0.88 JAK3 (0.53) JAK3BTKUSP30
SCHEMBL28918248 0.86 JAK3 (0.56) JAK3BTK
SCHEMBL28918249 0.86 JAK3 (0.56) JAK3BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656249-A2 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR Daewoong Pharmaceutical Co., Ltd. (KR) 2025-12-03 EP disclosed
EP-3478687-B1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR DAEWOONG PHARMACEUTICAL CO LTD (KR) 2024-03-20 EP disclosed
EP-3950691-A1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR Daewoong Pharmaceutical Co., Ltd. (KR) 2022-02-09 EP disclosed