SCHEMBL29448488

SCHEMBL29448488

CC(C)(C)OC(=O)N1CCC[C@@H](Nc2nc(Cl)nc3[nH]cc(C#N)c23)C1

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
JAK3 P52333 12/20 0.53
BTK Q06187 10/20 0.51
CHUK O15111 2/20 0.45
TTK P33981 1/20 0.43
PIK3CD O00329 1/20 0.42
PARP1 P09874 1/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
USP30 Q70CQ3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22496761 1.00 JAK3 (0.53) JAK3BTKCHUKTTKPIK3CD
SCHEMBL29448477 0.88 BTK (0.54) JAK3BTK
SCHEMBL22497106 0.88 BTK (0.54) JAK3BTK
SCHEMBL22496749 0.88 BTK (0.54) JAK3BTK
SCHEMBL22496733 0.88 JAK3 (0.52) JAK3BTKUSP30
SCHEMBL29448486 0.88 JAK3 (0.52) JAK3BTKUSP30
SCHEMBL28918226 0.88 JAK3 (0.52) JAK3BTKUSP30
SCHEMBL29448485 0.88 JAK3 (0.52) JAK3BTKUSP30
SCHEMBL28597542 0.86 JAK3 (0.58) JAK3BTKCHUKTTK
SCHEMBL28597543 0.86 JAK3 (0.58) JAK3BTKCHUKTTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656249-A2 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR Daewoong Pharmaceutical Co., Ltd. (KR) 2025-12-03 EP disclosed
EP-3478687-B1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR DAEWOONG PHARMACEUTICAL CO LTD (KR) 2024-03-20 EP disclosed
EP-3950691-A1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR Daewoong Pharmaceutical Co., Ltd. (KR) 2022-02-09 EP disclosed