Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29286674 | 0.90 | RAB9A (0.49) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL29448759 | 0.90 | RAB9A (0.49) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL29448790 | 0.90 | KCNK3 (0.51) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL29448781 | 0.89 | NPC1 (0.46) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL7076019 | 0.88 | NPC1 (0.60) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29448768 | 0.87 | KCNQ3 (0.47) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL20577799 | 0.87 | RAB9A (0.47) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL20578116 | 0.86 | RAB9A (0.49) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL20578151 | 0.86 | SMN1; SMN2 (0.52) | KMT2AMEN1MAPK14RAB9ANPC1 | |
| SCHEMBL29448809 | 0.85 | BRAF (0.46) | KMT2AMEN1MAPK14RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412670-B1 | PYRIDINE DERIVATIVES INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE THEREOF | SAMJIN PHARM CO LTD (KR) | 2022-03-09 | — | — | EP | disclosed |