Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29448796 | 0.85 | KMT2A (0.54) | MAPK14RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29286674 | 0.84 | RAB9A (0.49) | MAPK14RAB9AKMT2AMEN1MAOB | |
| SCHEMBL29448759 | 0.84 | RAB9A (0.49) | MAPK14RAB9AKMT2AMEN1MAOB | |
| SCHEMBL29448790 | 0.84 | KCNK3 (0.51) | MAPK14RAB9AKMT2AMEN1 | |
| SCHEMBL20577724 | 0.84 | SERPINE1 (0.51) | BRAFMAPK14SERPINE1KDM1ARAB9A | |
| SCHEMBL29448768 | 0.81 | KCNQ3 (0.47) | MAPK14RAB9AKMT2AMEN1MAOB | |
| SCHEMBL20577799 | 0.81 | RAB9A (0.47) | MAPK14RAB9AKMT2AMEN1KAT6A | |
| SCHEMBL20578151 | 0.80 | SMN1; SMN2 (0.52) | BRAFMAPK14RAB9AKMT2AMEN1 | |
| SCHEMBL20578116 | 0.80 | RAB9A (0.49) | BRAFMAPK14RAB9AKMT2AMEN1 | |
| SCHEMBL17920283 | 0.80 | PRKCI (0.48) | BRAFPRMT5WDR77KAT6ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412670-B1 | PYRIDINE DERIVATIVES INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE THEREOF | SAMJIN PHARM CO LTD (KR) | 2022-03-09 | — | — | EP | disclosed |