Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8735572 | 0.85 | CYP3A4 (0.41) | CYP3A4TDP1 | |
| SCHEMBL8735119 | 0.83 | CYP3A4 (0.39) | CYP3A4TDP1 | |
| Water SCHEMBL2944908 | 0.83 | CYP3A4 (0.39) | CYP3A4TDP1 | |
| SCHEMBL9550556 | 0.80 | KDM4E (0.37) | CYP3A4TDP1LTA4HALDH1A1 | |
| Ether SCHEMBL1679520 | 0.74 | CYP3A4 (0.60) | CYP3A4TDP1LTA4HALDH1A1 | |
| Ether SCHEMBL17061168 | 0.73 | CYP3A4 (0.57) | CYP3A4TDP1LTA4HALDH1A1 | |
| SCHEMBL163845 | 0.72 | TDP1 (0.41) | CYP3A4TDP1ALDH1A1 | |
| SCHEMBL3680019 | 0.71 | HDAC3 (0.42) | CYP3A4TDP1 | |
| Ether SCHEMBL28150517 | 0.71 | CYP3A4 (0.36) | CYP3A4TDP1LTA4HALDH1A1 | |
| SCHEMBL27456597 | 0.71 | CYP3A4 (0.36) | CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754907-B2 | Allosterically catalyzed signal amplification in chemical and biological sensing | NORTHWESTERN UNIVERSITY (US) | 2010-07-13 | — | — | US | claimed |
| US-20080213916-A1 | Allosterically Catalyzed Signal Amplification in Chemical and Biological Sensing | NORTHWESTERN UNIVERSITY (US) | 2008-09-04 | — | — | US | claimed |
| WO-2007018549-A9 | ALLOSTERICALLY CATALYZED SIGNAL AMPLIFICATION IN CHEMICAL AND BIOLOGICAL SENSING | UNIV NORTHWESTERN (US) | 2007-05-03 | — | — | WO | claimed |
| WO-2007018549-A2 | ALLOSTERICALLY CATALYZED SIGNAL AMPLIFICATION IN CHEMICAL AND BIOLOGICAL SENSING | NORTHWESTERN UNIVERSITY (US) | 2007-02-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080213916-A1 | Allosterically Catalyzed Signal Amplification in Chemical and Biological Sensing | CASR, MAVS, STAT3 | CYP3A4 1537/4885TDP1 2549/4885LTA4H 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.