Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451959 | 0.85 | ALDH1A1 (0.40) | NPBWR1HPGDALDH1A1NPC1MAPT | |
| SCHEMBL29451634 | 0.83 | ALDH1A1 (0.41) | HPGDALDH1A1NPC1MAPTKDM4E | |
| SCHEMBL29452152 | 0.83 | ALDH1A1 (0.41) | HPGDALDH1A1NPC1MAPTKDM4E | |
| SCHEMBL29451809 | 0.80 | HPGD (0.35) | NPBWR1HPGDALDH1A1NPC1MAPT | |
| SCHEMBL29452036 | 0.79 | MAPT (0.41) | NPBWR1HPGDALDH1A1NPC1MAPT | |
| SCHEMBL29451818 | 0.75 | MAPT (0.44) | NPBWR1HPGDALDH1A1NPC1MAPT | |
| SCHEMBL29451726 | 0.75 | ALDH1A1 (0.45) | NPBWR1HPGDALDH1A1NPC1MAPT | |
| SCHEMBL29451356 | 0.75 | ALDH1A1 (0.45) | NPBWR1HPGDALDH1A1NPC1MAPT | |
| SCHEMBL29451445 | 0.73 | ALDH1A1 (0.34) | HPGDALDH1A1NPC1MAPTKDM4E | |
| SCHEMBL29451475 | 0.71 | PRMT5 (0.39) | HPGDALDH1A1NPC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |