Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.41 |
| ▸ | HTT | P42858 | 11/20 | 0.41 |
| ▸ | NPC1 | O15118 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.41 |
| ▸ | MITF | O75030 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452152 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451356 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451726 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451809 | 0.84 | HPGD (0.35) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451445 | 0.83 | ALDH1A1 (0.34) | ALDH1A1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL29451680 | 0.83 | NPBWR1 (0.35) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL14501195 | 0.83 | HTT (0.44) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451492 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451369 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 | |
| SCHEMBL29451526 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HTTNPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |