Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.77 |
| ▸ | PDE2A | O00408 | 1/20 | 0.77 |
| ▸ | PDE5A | O76074 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.77 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.77 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446196 | 0.87 | ALDH1A1 (1.00) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL4073001 | 0.87 | ALDH1A1 (1.00) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL5485573 | 0.82 | ALDH1A1 (0.62) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL31195250 | 0.82 | ALDH1A1 (0.65) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL31195189 | 0.82 | ALDH1A1 (0.65) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL9346648 | 0.81 | ALDH1A1 (0.60) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL11021422 | 0.80 | ALDH1A1 (0.71) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL31195234 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL31195232 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL526905 | 0.79 | ALDH1A1 (0.59) | ALDH1A1CYP3A4PDE2APDE5AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |