Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.56 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346648 | 0.87 | ALDH1A1 (0.60) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL8866719 | 0.87 | KMT2A (0.53) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL29704102 | 0.85 | ALDH1A1 (0.59) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL10530375 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL468314 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL468316 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL138989 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL526905 | 0.85 | ALDH1A1 (0.59) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL8848558 | 0.85 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CYP3A4PDE2A | |
| SCHEMBL11763133 | 0.84 | ALDH1A1 (0.45) | ALDH1A1TSHRTDP1CYP3A4PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166585-B2 | 24-Sulfur-substituted analogs of 1α,25-dihydroxy vitamin D3 | CYTOCHROMA INC. (CA) | 2007-01-23 | — | — | US | disclosed |
| US-20040132695-A1 | 24-Sulfur-substituted analogs of 1 alpha, 25-dihydroxy vitamin D3 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-07-08 | — | — | US | disclosed |
| EP-1419143-A1 | 24-SULFUR-SUBSTITUTED ANALOGS OF 1ALPHA,25-DIHYDROXY VITAMIN D3 | JOHNS HOPKINS UNIVERSITY (US) | 2004-05-19 | — | — | EP | disclosed |
| US-20030149005-A1 | 24-sulfur-substituted analogs of 1alpha, 25-dihydroxy vitamin D3 | Opko IP Holdings II, Inc. (KY) | 2003-08-07 | — | — | US | disclosed |
| WO-2003018545-A1 | 24-SULFUR-SUBSTITUTED ANALOGS OF 1Α,25-DIHYDROXY VITAMIN D¿3? | JOHNS HOPKINS UNIVERSITY (US) | 2003-03-06 | — | — | WO | disclosed |
| US-4826806-A | CHROMOGENIC DYES | SHIN NISSO KAKO CO., LTD. (JP) | 1989-05-02 | — | — | US | disclosed |
| US-4382039-A | Process for the preparation of 4-nitrotoluene-2-sulphonic acid | BAYER AKTIENGESELLSCHAFT (DE) | 1983-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149005-A1 | 24-sulfur-substituted analogs of 1alpha, 25-dihydroxy vitamin D3 | CYP24A1, CYP2R1, CYP27B1 | ALDH1A1 333/4885TSHR 2069/4885TDP1 4167/4885 |
| US-20040132695-A1 | 24-Sulfur-substituted analogs of 1 alpha, 25-dihydroxy vitamin D3 | CYP24A1, CYP2R1, CYP27B1 | ALDH1A1 277/4885TSHR 2301/4885TDP1 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.