Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820480 | 0.86 | NR1H2 (0.43) | NR1H2HPGDUSP2SMN1; SMN2RECQL | |
| SCHEMBL15689694 | 0.80 | NR1H2 (0.49) | NR1H2CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL23070877 | 0.80 | EPHX1 (0.47) | NR1H2HPGDUSP2SMN1; SMN2RECQL | |
| SCHEMBL30713542 | 0.78 | NR1H2 (0.47) | NR1H2CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL30722401 | 0.77 | USP2 (0.37) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL2943268 | 0.75 | NR1H2 (0.44) | NR1H2CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL1141357 | 0.74 | USP2 (0.43) | NR1H2HPGDUSP2SMN1; SMN2RECQL | |
| SCHEMBL21906695 | 0.74 | USP2 (0.43) | NR1H2HPGDUSP2SMN1; SMN2RECQL | |
| SCHEMBL27225356 | 0.74 | USP2 (0.43) | NR1H2HPGDUSP2SMN1; SMN2RECQL | |
| SCHEMBL30713619 | 0.74 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101084215-B | Piperidine and azetidine derivatives as GLYT1 inhibitors | MERCK SHARP & DOHME | 2013-10-30 | — | — | CN | disclosed |
| EP-1831201-B1 | PIPERIDINE AND AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS | MERCK SHARP & DOHME (GB) | 2010-08-04 | — | — | EP | disclosed |
| US-7655644-B2 | Piperidine and azetidine derivatives as GlyT1 inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2010-02-02 | — | — | US | disclosed |
| US-20080090796-A1 | Piperidine And Azetidine Derivatives As Glyt1 Inhibitors | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2008-04-17 | — | — | US | disclosed |
| CN-101084215-A | Piperidine and azetidine derivatives as GLYT1 inhibitors | MERCK SHARP & DOHME (GB) | 2007-12-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090796-A1 | Piperidine And Azetidine Derivatives As Glyt1 Inhibitors | SLC6A7, SLC1A1, SLC1A2 | NR1H2 1583/4885CHRM2 742/4885CHRM1 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.