Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451791 | 0.84 | PRMT5 (0.59) | TP53THRBMAPTPOLBNPC1 | |
| SCHEMBL29451580 | 0.81 | RAB9A (0.69) | THRBMAPTPOLBNPC1KMT2A | |
| SCHEMBL29451936 | 0.81 | PRMT5 (0.68) | THRBMAPTPOLBKMT2AALDH1A1 | |
| SCHEMBL29451947 | 0.80 | MAPT (0.48) | TP53THRBMAPTPOLBNPC1 | |
| SCHEMBL29451789 | 0.74 | PRMT5 (0.77) | PRMT5WDR77RIOK1 | |
| SCHEMBL29451903 | 0.67 | PRMT5 (0.58) | TP53MAPTPOLBNPC1KMT2A | |
| SCHEMBL26982634 | 0.66 | LMNA (0.49) | TP53POLBKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL26730522 | 0.66 | KAT2B (0.48) | TP53MAPTPOLBNPC1KMT2A | |
| SCHEMBL12971593 | 0.65 | POLB (0.58) | MAPTPOLBNPC1KMT2AALDH1A1 | |
| SCHEMBL29452022 | 0.64 | TSHR (0.55) | POLBKMT2AALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |