Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451292 | 0.76 | L3MBTL1 (0.56) | POLBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5656645 | 0.76 | ALDH1A1 (0.56) | POLBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6793540 | 0.72 | ALDH1A1 (0.59) | POLBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6187792 | 0.72 | ALDH1A1 (0.54) | POLBALDH1A1MAPTKMT2AAPOBEC3A | |
| SCHEMBL4844382 | 0.71 | ALDH1A1 (0.70) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL6787809 | 0.71 | POLB (0.65) | POLBALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL29451495 | 0.70 | L3MBTL1 (0.64) | ALDH1A1MAPTSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL16375352 | 0.70 | ALDH1A1 (0.54) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL6187801 | 0.69 | KMT2A (0.51) | POLBALDH1A1MAPTKMT2AAPOBEC3A | |
| SCHEMBL6787331 | 0.69 | POLB (0.57) | POLBALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |