Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451495 | 0.87 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL4617110 | 0.87 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451450 | 0.87 | POLB (0.55) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451717 | 0.84 | MAPT (0.53) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451535 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29452201 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL4618419 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451543 | 0.81 | KDM4E (0.49) | MAPTKDM4ERAB9AMEN1KMT2A | |
| SCHEMBL29451291 | 0.81 | MAPT (0.53) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451278 | 0.78 | MEN1 (0.48) | ALDH1A1MAPTKDM4EPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |