Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451495 | 0.87 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451986 | 0.87 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451450 | 0.87 | POLB (0.55) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451717 | 0.84 | MAPT (0.53) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29451535 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL4618419 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL29452201 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL4616183 | 0.82 | RAB9A (0.53) | L3MBTL1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL4615532 | 0.81 | KDM4E (0.49) | ALDH1A1MAPTKDM4EPKMRAB9A | |
| SCHEMBL29451560 | 0.81 | KDM4E (0.49) | ALDH1A1MAPTKDM4EPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | L3MBTL1 4156/4885ALDH1A1 1865/4885MAPT 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.