Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP5 | P45974 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532201 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2AKMOPRNP | |
| SCHEMBL29451973 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4EKMT2AHPGDRAB9A | |
| SCHEMBL29452059 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4EKMT2AHPGDRAB9A | |
| SCHEMBL29452015 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4EKMT2AKMOHCAR2 | |
| SCHEMBL29452082 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4EKMT2AKMOHCAR2 | |
| SCHEMBL29452023 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4EKMT2AKMOHCAR2 | |
| SCHEMBL29451708 | 0.72 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2APRNPHPGD | |
| SCHEMBL31306244 | 0.71 | KDM4E (0.43) | ALDH1A1KDM4EKMT2AKMOPRNP | |
| SCHEMBL1155928 | 0.69 | ALDH1A1 (0.59) | ALDH1A1KDM4EKMT2APRNPHPGD | |
| SCHEMBL29451403 | 0.68 | KDM4E (0.42) | ALDH1A1KDM4EKMT2AKMOPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |