Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 4/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452023 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KMOPRMT5WDR77RIOK1 | |
| SCHEMBL29452082 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KMOPRMT5WDR77RIOK1 | |
| SCHEMBL29451637 | 0.83 | PRMT5 (0.39) | ALDH1A1KMOPRMT5WDR77RIOK1 | |
| SCHEMBL29451475 | 0.83 | PRMT5 (0.39) | ALDH1A1KMOPRMT5WDR77RIOK1 | |
| SCHEMBL4532201 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KMOKDM4EKMT2AHCAR2 | |
| SCHEMBL31180570 | 0.80 | KMO (0.38) | KMOPRMT5WDR77RIOK1KDM4E | |
| SCHEMBL29452006 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KMOKDM4EKMT2AHCAR2 | |
| SCHEMBL31015065 | 0.79 | KMO (0.37) | KMOPRMT5WDR77RIOK1KMT2A | |
| SCHEMBL29451403 | 0.75 | KDM4E (0.42) | ALDH1A1KMOKDM4EKMT2AKDM4C | |
| SCHEMBL29451492 | 0.73 | ALDH1A1 (0.44) | ALDH1A1PRMT5WDR77KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |