Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451823 | 0.85 | KDM4E (0.40) | KDM4EPTK2PRMT5WDR77BACE1 | |
| SCHEMBL29452187 | 0.83 | PRMT5 (0.46) | KDM4EPRMT5WDR77RIOK1ALDH1A1 | |
| SCHEMBL29451915 | 0.83 | PRMT5 (0.46) | KDM4EPRMT5WDR77RIOK1ALDH1A1 | |
| SCHEMBL29451485 | 0.81 | PRMT5 (0.46) | KDM4EPTK2PRMT5WDR77RIOK1 | |
| SCHEMBL29452153 | 0.75 | PRMT5 (0.35) | KDM4EPRMT5WDR77RIOK1BACE2 | |
| SCHEMBL29451486 | 0.70 | PRMT5 (0.47) | KDM4EPRMT5WDR77RIOK1ALDH1A1 | |
| SCHEMBL29451755 | 0.69 | KCNJ6 (0.52) | KDM4EPRMT5WDR77RIOK1ALDH1A1 | |
| SCHEMBL29451674 | 0.67 | PRMT5 (0.59) | PRMT5WDR77RIOK1ALDH1A1RECQL | |
| SCHEMBL29452006 | 0.65 | ALDH1A1 (0.44) | KDM4EALDH1A1POLBLMNA | |
| SCHEMBL29451286 | 0.61 | CA12 (0.47) | KDM4EALDH1A1POLBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |