Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.43 |
| ▸ | HTT | P42858 | 12/20 | 0.43 |
| ▸ | RAB9A | P51151 | 11/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.43 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451267 | 0.88 | ALDH1A1 (0.42) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL1010562 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29452152 | 0.80 | ALDH1A1 (0.41) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29451634 | 0.80 | ALDH1A1 (0.41) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29451901 | 0.77 | ALDH1A1 (0.44) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29451777 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29452103 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29451356 | 0.72 | ALDH1A1 (0.45) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29451726 | 0.72 | ALDH1A1 (0.45) | ALDH1A1HTTRAB9ANPSR1NPC1 | |
| SCHEMBL29451421 | 0.71 | ALDH1A1 (0.44) | ALDH1A1HTTRAB9ANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |