Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11200997 | 0.83 | TSHR (0.65) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8140330 | 0.83 | TSHR (0.75) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1439966 | 0.83 | TSHR (0.75) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL10876385 | 0.81 | SMN1; SMN2 (0.62) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL5342056 | 0.81 | TSHR (0.71) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7837749 | 0.81 | SMN1; SMN2 (0.77) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL12086998 | 0.81 | TSHR (0.61) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1299167 | 0.80 | TSHR (0.68) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1121460 | 0.79 | SMN1; SMN2 (0.59) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8514786 | 0.76 | TSHR (0.75) | TSHRCYP3A4CYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |